Speaker Search Results

Scientific Sessions

Jacopo da Bertinoro

19.5.2024

16:30 – 18:00h

OPENING SESSION: Clinical relevance of transglutaminases

Chairs: Elisabetta Verderio Edwards Jeffrey Keillor

Opening Lecture 1: IUBMB LECTURE - Targeted covalent inhibition of transglutaminase
Jeffrey Keillor (University of Ottawa, Canada)

16:40h - 17:20h

Scientific Sessions

Jacopo da Bertinoro

19.5.2024

16:30 – 18:00h

OPENING SESSION: Clinical relevance of transglutaminases

Chairs: Elisabetta Verderio Edwards Jeffrey Keillor

Opening Lecture 2: Developing a TG2 therapeutic molecule
Timothy Johnson (Mestag Therapeutics, UK)

17:20h - 18:00h

Scientific Sessions

Jacopo da Bertinoro

20.5.2024

08:30 – 10:05h

EMERGING DISEASES, Pt.1

Chairs: László Fésüs Ebrahimi Samani

Factor XIII-A at the interface of coagulation, inflammation and metabolic health
Mari Kaartinen (McGill University, Canada)

08:50h - 09:20h

Scientific Sessions

Jacopo da Bertinoro

20.5.2024

08:30 – 10:05h

EMERGING DISEASES, Pt.1

Chairs: László Fésüs Ebrahimi Samani

Transglutaminases, mucus barrier integrity and disease
Christian Recktenwald (University of Gothenburg, Sweden)

09:20h - 09:50h

Scientific Sessions

Jacopo da Bertinoro

20.5.2024

15:00 – 16:20h

CARDIOVASCULAR DISEASES, Pt.1

Chairs: Lakshmi Santhanam Paulina Stoklova

Detection of transglutaminase expression and activity at the maternal-fetal interface
Michal Neeman (Weizmann Institute of Science, Israel)

15:20h - 15:50h

Scientific Sessions

Jacopo da Bertinoro

20.5.2024

15:00 – 16:20h

CARDIOVASCULAR DISEASES, Pt.1

Chairs: Lakshmi Santhanam Paulina Stoklova

Let's cross-link: diverse functions of Factor XIII-A
Nicola Mutch (University of Aberdeen, UK)

15:50h - 16:20h

Scientific Sessions

Jacopo da Bertinoro

21.5.2024

08:15 – 10:00h

FIBROSIS, Pt.1

Chairs: Timothy Johnson Judit Prat Duran

Introduction
Timothy Johnson (Mestag Therapeutics, UK)

08:15h - 08:30h

Scientific Sessions

Jacopo da Bertinoro

21.5.2024

08:15 – 10:00h

FIBROSIS, Pt.1

Chairs: Timothy Johnson Judit Prat Duran

Inhibition of transglutaminase 2 in pulmonary fibrosis
Thomas Thatcher (Virginia Commonwealth University, US)

08:30h - 09:00h

Scientific Sessions

Jacopo da Bertinoro

21.5.2024

08:15 – 10:00h

FIBROSIS, Pt.1

Chairs: Timothy Johnson Judit Prat Duran

Transglutaminase 2 in scleroderma and experimentally-induced dermal fibrosis
David Abraham (UCL, UK)

09:00h - 09:30h

Scientific Sessions

Jacopo da Bertinoro

19.5.2024

16:30 – 18:00h

OPENING SESSION: Clinical relevance of transglutaminases

Chairs: Elisabetta Verderio Edwards Jeffrey Keillor

Introduction
Daniel Aeschlimann (Cardiff University, UK) & Elisabetta Verderio Edwards

16:30h - 16:40h

Scientific Sessions

Jacopo da Bertinoro

21.5.2024

15:00 – 16:10h

CELIAC DISEASE and INFLAMMATION, Pt.1

Chairs: Mauro Piacenti Pauline Navals

Introduction
Mauro Piacentini

15:00h - 15:20h

Scientific Sessions

Jacopo da Bertinoro

21.5.2024

15:00 – 16:10h

CELIAC DISEASE and INFLAMMATION, Pt.1

Chairs: Mauro Piacenti Pauline Navals

Pathogenic transglutaminases in gluten sensitive disorders
Ludvig Sollid (University of Oslo, Norway)

15:20h - 15:50h

Scientific Sessions

Jacopo da Bertinoro

21.5.2024

15:00 – 16:10h

CELIAC DISEASE and INFLAMMATION, Pt.1

Chairs: Mauro Piacenti Pauline Navals

Transglutaminase 2 inhibitor protects from gluten-induced intestinal damage in celiac disease - Transcriptomic analysis of a randomized gluten challenge study
Keijo Viiri (Tampere University, Finland)

15:50h - 16:20h

Scientific Sessions

Jacopo da Bertinoro

22.5.2024

08:20 – 09:40h

CANCER & SIGNALLING DISORDERS, Pt.1

Chairs: Daniela Matei Luca Occhigrossi

Introduction
Daniela Matei (Northwestern University, US)

08:20h - 08:40h

Scientific Sessions

Jacopo da Bertinoro

22.5.2024

08:20 – 09:40h

CANCER & SIGNALLING DISORDERS, Pt.1

Chairs: Daniela Matei Luca Occhigrossi

Activation of integrin-linked kinase and β-catenin in ovarian cancer: role of TG2
Salvatore Condello (Indiana University School of Medicine, US)

08:40h - 09:10h

Scientific Sessions

Jacopo da Bertinoro

22.5.2024

08:20 – 09:40h

CANCER & SIGNALLING DISORDERS, Pt.1

Chairs: Daniela Matei Luca Occhigrossi

Unraveling the roles of the Transglutaminase 2 in breast cancer cells
Nicoletta Bianchi (University of Ferrara, Italy)

09:10h - 09:40h

Scientific Sessions

Jacopo da Bertinoro

22.5.2024

14:20 – 15:40h

NEUROLOGICAL DISEASES, Pt.1

Chairs: Gail Johnson Fiorella Colasuonno

Introduction
Gail Johnson (University of Rochester, US)

14:20h - 14:40h

Scientific Sessions

Jacopo da Bertinoro

22.5.2024

14:20 – 15:40h

NEUROLOGICAL DISEASES, Pt.1

Chairs: Gail Johnson Fiorella Colasuonno

Comparing pathological roles of TG2 in spinal cord injury and multiple sclerosis
Mousumi Ghosh (University of Miami, US)

15:10h - 15:40h

Scientific Sessions

Jacopo da Bertinoro

22.5.2024

14:20 – 15:40h

NEUROLOGICAL DISEASES, Pt.1

Chairs: Gail Johnson Fiorella Colasuonno

Counteracting Alzheimer’s disease pathological brain lesions: is TG1 or TG2 the pharmacological target?
Micha Wilhelmus (Amsterdam University MC, The Netherlands)

14:40h - 15:10h

Scientific Sessions

Jacopo da Bertinoro

20.5.2024

08:30 – 10:05h

EMERGING DISEASES, Pt.1

Chairs: László Fésüs Ebrahimi Samani

Introduction
László Fésüs (University of Debrecen, Hungary)

08:30h - 08:50h

Scientific Sessions

Jacopo da Bertinoro

20.5.2024

10:45 – 12:30h

EMERGING DISEASES, Pt.2

Chairs: László Fésüs Ebrahimi Samani

Tissue transglutaminase as a double-edged sword in cell survival, inflammation and cell death processes
Károly Jambrovics (University of Debrecen, Hungary)

10:45h - 11:15h

Scientific Sessions

Jacopo da Bertinoro

20.5.2024

10:45 – 12:30h

EMERGING DISEASES, Pt.2

Chairs: László Fésüs Ebrahimi Samani

Molecular basis of ubiquitination catalyzed by the bacterial transglutaminase
Zhao-Qing Luo (Purdue University, US)

11:15h - 11:45h

Scientific Sessions

Jacopo da Bertinoro

20.5.2024

10:45 – 12:30h

EMERGING DISEASES, Pt.2

Chairs: László Fésüs Ebrahimi Samani

Generation and phenotype analysis of conditional TG1 knockout mice reveal possible new function in gastrointestinal tract
Abstract selected young scientist talk 1: Atsuki Takahashi (Nagoya University, Japan)

11:45h - 12:00h

Scientific Sessions

Jacopo da Bertinoro

20.5.2024

15:00 – 16:20h

CARDIOVASCULAR DISEASES, Pt.1

Chairs: Lakshmi Santhanam Paulina Stoklova

Introduction
Lakshmi Santhanam (Johns Hopkins University, US)

15:00h - 15:20h

Scientific Sessions

Jacopo da Bertinoro

20.5.2024

16:40 – 17:55h

CARDIOVASCULAR DISEASES, Pt.2

Chairs: Lakshmi Santhanam Paulina Stoklova

Transglutaminase 2 role in vasodilatation and vascular dysfunction
Estéfano Pinilla (Aarhus University, Denmark)

16:40h - 17:10h

Scientific Sessions

Jacopo da Bertinoro

20.5.2024

16:40 – 17:55h

CARDIOVASCULAR DISEASES, Pt.2

Chairs: Lakshmi Santhanam Paulina Stoklova

Tissue Transglutaminase 2 a potential fibrin crosslinking agent
Abstract selected young scientist talk 1: Paulina Stoklova (University of Bern, Switzerland)

17:10h - 17:25h

Scientific Sessions

Jacopo da Bertinoro

20.5.2024

16:40 – 17:55h

CARDIOVASCULAR DISEASES, Pt.2

Chairs: Lakshmi Santhanam Paulina Stoklova

Conformation dependency of human transglutaminase 2 interactome upon modulator treatments in HUVEC cells
Abstract selected young scientist talk 2: Bianka Csaholczi (University of Debrecen, Hungary)

17:25h - 17:40h

Scientific Sessions

Jacopo da Bertinoro

20.5.2024

16:40 – 17:55h

CARDIOVASCULAR DISEASES, Pt.2

Chairs: Lakshmi Santhanam Paulina Stoklova

Single molecule display coupled with next generation sequencing and bioinformatics for rapid substrate profiling of transglutaminases
Abstract selected young scientist talk 3: Jasmina Corovic (Nagoya University, Japan)

17:40h - 17:55h

Scientific Sessions

Jacopo da Bertinoro

21.5.2024

10:20 – 11:00h

FIBROSIS, Pt.2

Chairs: Timothy Johnson Judit Prat Duran

Abstract selected young scientist talk 1: Novel α-ketomethylamides as potent reversible acting TG2 inhibitors for the treatment of fibrotic disease
Christian Büchold (Zedira)

10:20h - 10:40h

Scientific Sessions

Jacopo da Bertinoro

21.5.2024

10:20 – 11:00h

FIBROSIS, Pt.2

Chairs: Timothy Johnson Judit Prat Duran

Abstract selected young scientist talk 2: SPECT based measurement of Zampilimab target occupancy in mouse lung using hTG2expressing cells
Erica Ferrini (Chiesi)

10:40h - 11:00h

Scientific Sessions

Jacopo da Bertinoro

21.5.2024

17:00 – 18:30h

CELIAC DISEASE and INFLAMMATION, Pt.2

Chairs: Mauro Piacentini Pauline Navals

Defective proteostasis in celiac disease: role of TG2
Villella Valeria (University of Naples Federico II, Italy)

17:00h - 17:30h

Scientific Sessions

Jacopo da Bertinoro

21.5.2024

17:00 – 18:30h

CELIAC DISEASE and INFLAMMATION, Pt.2

Chairs: Mauro Piacentini Pauline Navals

The intestinal B cell response to TG2 in celiac disease
Marie Fleur du Pre' (University of Oslo, Norway)

17:30h - 18:00h

Scientific Sessions

Jacopo da Bertinoro

21.5.2024

17:00 – 18:30h

CELIAC DISEASE and INFLAMMATION, Pt.2

Chairs: Mauro Piacentini Pauline Navals

Type 2 transglutaminase participates in defining the celiac cellular phenotype
Abstract selected young scientist talk: Antonio Montefusco (Università degli Studi Salerno, Italy)

18:00h - 18:15h

Scientific Sessions

Jacopo da Bertinoro

22.5.2024

10:20 – 11:50h

CANCER & SIGNALLING DISORDERS, Pt.2

Chairs: Daniela Matei Luca Occhigrossi

Cotargeting tissue transglutaminase-fibronectin interaction and its drug escape pathways to prevent ovarian cancer dissemination
Abstract selected young scientist talk 1: Monica Tudor (Institute of Biochemistry of the Romanian Academy, Romenia)

10:50h - 11:05h

Scientific Sessions

Jacopo da Bertinoro

22.5.2024

10:20 – 11:50h

CANCER & SIGNALLING DISORDERS, Pt.2

Chairs: Daniela Matei Luca Occhigrossi

Transglutaminase 2 controls metabolic reprogramming in hepatocellular carcinoma
Federica Rossin (University of Rome Tor Vergata, Italy)

10:20h - 10:50h

Scientific Sessions

Jacopo da Bertinoro

22.5.2024

10:20 – 11:50h

CANCER & SIGNALLING DISORDERS, Pt.2

Chairs: Daniela Matei Luca Occhigrossi

Transglutaminase-2 gene silencing to unravel the cancer progression mechanisms in glioblastoma
Abstract selected young scientist talk 2: Amalia Luce (University of Campania "Luigi Vanvitelli", Italy -Nottingham Trent University, UK)

11:05h - 11:20h

Scientific Sessions

Jacopo da Bertinoro

22.5.2024

10:20 – 11:50h

CANCER & SIGNALLING DISORDERS, Pt.2

Chairs: Daniela Matei Luca Occhigrossi

Transglutaminase type 2 tunes melanoma cell metabolism during phenotype switching
Abstract selected young scientist talk 3: Federica Vianello (University of Padova, Italy)

11:20h - 11:35h

Scientific Sessions

Jacopo da Bertinoro

22.5.2024

16:00 – 17:00h

NEUROLOGICAL DISEASES, Pt.2

Chairs: Gail Johnson Fiorella Colasuonno

Depletion of astrocytic TG2 enhances the ability of astrocytes to metabolically support neurons through lipid metabolism
Abstract selected young scientist talk 1: Thomas Delgado (University of Rochester, US)

16:30h - 16:45h

Scientific Sessions

Jacopo da Bertinoro

22.5.2024

16:00 – 17:00h

NEUROLOGICAL DISEASES, Pt.2

Chairs: Gail Johnson Fiorella Colasuonno

Transglutaminase 2 on extracellular vesicles released by glial cells: possible implication in Alzheimer’s disease
Martina Gabrielli (CNR, Italy)

16:00h - 16:30h

Chairs' welcome/conclusion

Jacopo da Bertinoro

19.5.2024

16:15 – 16:30h

WELCOME SESSION

Chairs: Elisabetta Verderio Edwards Kiyotaka Hitomi

Welcome note and programme outline
Elisabetta Verderio Edwards & Kiyotaka Hitomi (Chairs)

16:15h - 16:30h

Scientific Sessions

Jacopo da Bertinoro

19.5.2024

16:30 – 18:00h

OPENING SESSION: Clinical relevance of transglutaminases

Chairs: Elisabetta Verderio Edwards Jeffrey Keillor

Tribute to Prof Soichi Kojima
Kiyotaka Hitomi (Nagoya University, Japan)

18:00h - 18:10h

Scientific Sessions

Jacopo da Bertinoro

20.5.2024

10:45 – 12:30h

EMERGING DISEASES, Pt.2

Chairs: László Fésüs Ebrahimi Samani

Transglutaminase 2 regulates the STING pathway: a new therapeutic target for bacterial infections in cystic fibrosis
Abstract selected young scientist talk 2: Luca Occhigrossi (University of Rome Tor Vergata, Italy)

12:00h - 12:15h

Scientific Sessions

Jacopo da Bertinoro

20.5.2024

10:45 – 12:30h

EMERGING DISEASES, Pt.2

Chairs: László Fésüs Ebrahimi Samani

Transglutaminase 1 – a novel regulator of osteoclastogenesis: insights from in vitro and in vivo studies
Abstract selected young scientist talk 3: Sahar Ebrahimi Samani (McGill University, Canada)

12:15h - 12:30h

Scientific Sessions

Jacopo da Bertinoro

21.5.2024

08:15 – 10:00h

FIBROSIS, Pt.1

Chairs: Timothy Johnson Judit Prat Duran

Research on the induction mechanism of fibrosis initiated by TG2
Hideki Tatsukawa (Nagoya University, Japan)

09:30h - 10:00h

Scientific Sessions

Jacopo da Bertinoro

21.5.2024

17:00 – 18:30h

CELIAC DISEASE and INFLAMMATION, Pt.2

Chairs: Mauro Piacentini Pauline Navals

Structural and mechanistic analysis of calcium dependent regulation of Transglutaminase 2 activity using a calcium bound intermediate state
Young IUBMB scientist talk: Agnele Sewa (Stanford University, US)

18:15h - 18:30h

Scientific Sessions

Jacopo da Bertinoro

22.5.2024

10:20 – 11:50h

CANCER & SIGNALLING DISORDERS, Pt.2

Chairs: Daniela Matei Luca Occhigrossi

Suppressing the GTP-Binding Activity of Tissue Transglutaminase with Irreversible Inhibitors: Size Doesn’t Matter
Abstract selected young scientist talk 4: Pauline Navals (University of Ottawa, Canada)

11:35h - 11:50h

Scientific Sessions

Jacopo da Bertinoro

22.5.2024

16:00 – 17:00h

NEUROLOGICAL DISEASES, Pt.2

Chairs: Gail Johnson Fiorella Colasuonno

The loss of function of transglutaminase 6 induces locomotor impairment in vivo with a sex bias
Abstract selected young scientist talk 2: Luisa Donini (University of Trento, Italy)

16:45h - 17:00h

Social Activities

Garden

22.5.2024

17:15 – 19:30h

WINERY TOUR

WALK TO THE WINERY
(30 min in the field)

17:15h - 18:00h

Scientific Sessions

Jacopo da Bertinoro

19.5.2024

16:30 – 18:00h

OPENING SESSION: Clinical relevance of transglutaminases

Chairs: Elisabetta Verderio Edwards Jeffrey Keillor

FEBS WELCOME
Beata Vertessy  (FEBS Advanced Course Committee)

18:10h - 18:30h

Scientific Sessions

Jacopo da Bertinoro

20.5.2024

08:30 – 10:05h

EMERGING DISEASES, Pt.1

Chairs: László Fésüs Ebrahimi Samani

Transglutaminase 2 is required for proper skeletal muscle development and tissue repair, as well as for tooth enamel development
Zsuzsa Szondy (University of Debrecen, Hungary)

09:50h - 10:05h